| Title |
Oxidants, antioxidants and the current incurability of metastatic cancers
|
|---|---|
| Published in |
Open Biology, January 2013
|
| DOI | 10.1098/rsob.120144 |
| Pubmed ID | |
| Authors |
Jim Watson |
| Abstract |
The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antioxidants that effectively block otherwise highly effective oxidant therapies. Also key to better understanding is why and how the anti-diabetic drug metformin (the world's most prescribed pharmaceutical product) preferentially kills oxidant-deficient mesenchymal p53(- -) cells. A much faster timetable should be adopted towards developing more new drugs effective against p53(- -) cancers. |
X Demographics
The data shown below were collected from the profiles of 358 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 81 | 23% |
| Spain | 39 | 11% |
| United Kingdom | 22 | 6% |
| Mexico | 18 | 5% |
| Canada | 6 | 2% |
| Netherlands | 5 | 1% |
| Germany | 4 | 1% |
| Ireland | 4 | 1% |
| Venezuela, Bolivarian Republic of | 3 | <1% |
| Other | 48 | 13% |
| Unknown | 128 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 261 | 73% |
| Scientists | 53 | 15% |
| Practitioners (doctors, other healthcare professionals) | 32 | 9% |
| Science communicators (journalists, bloggers, editors) | 12 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 537 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 2% |
| United Kingdom | 10 | 2% |
| Spain | 5 | <1% |
| Australia | 4 | <1% |
| Germany | 3 | <1% |
| Brazil | 3 | <1% |
| Nigeria | 2 | <1% |
| Canada | 2 | <1% |
| Israel | 1 | <1% |
| Other | 11 | 2% |
| Unknown | 484 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 119 | 22% |
| Student > Ph. D. Student | 102 | 19% |
| Student > Master | 53 | 10% |
| Other | 40 | 7% |
| Professor | 38 | 7% |
| Other | 138 | 26% |
| Unknown | 47 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 183 | 34% |
| Medicine and Dentistry | 86 | 16% |
| Biochemistry, Genetics and Molecular Biology | 71 | 13% |
| Chemistry | 47 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 3% |
| Other | 70 | 13% |
| Unknown | 65 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 532. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2022.
All research outputs
#47,426
of 25,713,737 outputs
Outputs from Open Biology
#1
of 1,178 outputs
Outputs of similar age
#214
of 290,832 outputs
Outputs of similar age from Open Biology
#1
of 14 outputs
Altmetric has tracked 25,713,737 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,178 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.