The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting Cell-Intrinsic and Cell-Extrinsic Mechanisms of Intravasation in Invasive Breast Cancer
|
|---|---|
| Published in |
Science Signaling, November 2014
|
| DOI | 10.1126/scisignal.aaa2104 |
| Pubmed ID | |
| Authors |
Jiri Keirsse, Damya Laoui, Eva Van Overmeire, Jo A Van Ginderachter |
| Abstract |
The survival of breast cancer patients with metastatic disease has not markedly improved over recent decades, highlighting the need to better understand this process. In this issue of Science Signaling, Pignatelli et al. used freshly obtained invasive ductal carcinoma cells from patients to demonstrate the need for high abundance of the invasive isoform of the Mena protein (Mena(INV)) in cancer cells and colony-stimulating factor 1 (CSF-1)-mediated paracrine signaling in macrophages for efficient transendothelial migration and metastasis formation in all clinical breast cancer subtypes. Furthermore, the triple negative and HER2(+) subtypes, but not the ERPR(+)/HER2(-) subtype, had high CSF-1 receptor (CSF-1R) abundance and also partially used autocrine CSF-1/CSF-1R signaling for invasion. These data establish Mena(INV), CSF-1/CSF-1R, and macrophages as potential therapeutic targets for most human breast cancers. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 37% |
| Netherlands | 1 | 5% |
| Spain | 1 | 5% |
| Germany | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 8 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Scientists | 6 | 32% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Unknown | 23 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 42% |
| Student > Master | 3 | 13% |
| Other | 2 | 8% |
| Professor > Associate Professor | 2 | 8% |
| Student > Ph. D. Student | 2 | 8% |
| Other | 3 | 13% |
| Unknown | 2 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 42% |
| Medicine and Dentistry | 4 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Immunology and Microbiology | 2 | 8% |
| Earth and Planetary Sciences | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 4 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2014.
All research outputs
#2,937,690
of 25,888,937 outputs
Outputs from Science Signaling
#1,066
of 3,559 outputs
Outputs of similar age
#39,156
of 371,926 outputs
Outputs of similar age from Science Signaling
#21
of 63 outputs
Altmetric has tracked 25,888,937 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,559 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.