Title |
Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
|
---|---|
Published in |
Journal of Pharmaceutical & Biomedical Analysis, June 2016
|
DOI | 10.1016/j.jpba.2016.06.003 |
Pubmed ID | |
Authors |
Ahmed Mediani, Faridah Abas, M. Maulidiani, Alfi Khatib, Chin Ping Tan, Intan Safinar Ismail, Khozirah Shaari, Amin Ismail, N.H. Lajis |
Abstract |
Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague-Dawley rats was achieved by a low dose of streptozotocin (STZ) (25mg/kgbw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500mg/kg bw) of P. niruri via metabolomics approach. The administration of 500mg/kgbw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 124 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 17% |
Student > Bachelor | 14 | 11% |
Student > Master | 12 | 10% |
Lecturer | 8 | 6% |
Researcher | 6 | 5% |
Other | 22 | 18% |
Unknown | 42 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 15% |
Chemistry | 13 | 10% |
Medicine and Dentistry | 12 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Other | 12 | 10% |
Unknown | 50 | 40% |