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Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia

Overview of attention for article published in Electronic Physician, July 2014
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Title
Rhabdomyolysis due to Lamivudine administration in acute viral hepatitis B infection: a case report from Malaysia
Published in
Electronic Physician, July 2014
DOI 10.14661/2014.863-867
Pubmed ID
Authors

Janudin Baharin, Narisa Sulaiman Sahari, Sazlyna Mohd Sazlly Lim

Abstract

Rhabdomyolysis is a serious but rare side effect of Lamivudine treatment. Therefore, appropriate biochemical monitoring should be undertaken when it is used in the treatment of hepatitis B. This paper presents a case of Lamivudine-associated rhabdomyolysis in a 31-year-old man with congenital heart disease and hepatitis B. Three days after starting Lamivudine, the patient developed myalgia. Significant muscle tenderness and swelling of the upper and lower limbs was discovered during a physical examination. Creatine kinase was markedly raised. Lamivudine-induced rhabdomyolysis was suspected and the drug was discontinued. Symptoms and creatine kinase activity improved within four days of Lamivudine cessation and hydration. Early identification of Lamivudine-induced rhabdomyolysis is key in preventing this potentially fatal drug reaction; withdrawal of Lamivudine may contribute to complete remission of rhabdomyolysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 31%
Student > Postgraduate 3 23%
Student > Master 2 15%
Lecturer 1 8%
Unspecified 1 8%
Other 1 8%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Unspecified 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Psychology 1 8%
Nursing and Health Professions 1 8%
Other 2 15%
Unknown 3 23%