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Mendeley readers
Attention Score in Context
| Title |
Analysis of MTHFR and MTRR Gene Polymorphisms in Iranian Ventricular Septal Defect Subjects
|
|---|---|
| Published in |
International Journal of Molecular Sciences, January 2013
|
| DOI | 10.3390/ijms14022739 |
| Pubmed ID | |
| Authors |
Seyyed Reza Pishva, Ramachandran Vasudevan, Ali Etemad, Farzad Heidari, Makanko Komara, Patimah Ismail, Fauziah Othman, Abdollah Karimi, Mohammad Reza Sabri |
| Abstract |
Ventricular septal defect (VSD) is one of the most common types of congenital heart defects (CHD). There are vivid multifactorial causes for VSD in which both genetic and environmental risk factors are consequential in the development of CHD. Methionine synthase reductase (MTRR) and methylenetetrahydrofolate reductase (MTHFR) are two of the key regulatory enzymes involved in the metabolic pathway of homocysteine. Genes involved in homocysteine/folate metabolism may play an important role in CHDs. In this study; we determined the association of A66G and C524T polymorphisms of the MTRR gene and C677T polymorphism of the MTHFR gene in Iranian VSD subjects. A total of 123 children with VSDs and 125 healthy children were included in this study. Genomic DNA was extracted from the buccal cells of all the subjects. The restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) method was carried out to amplify the A66G and C524T polymorphism of MTRR and C677T polymorphism of MTHFR genes digested with Hinf1, Xho1 and Nde1 enzymes, respectively. The genotype frequencies of CC, CT and TT of MTRR gene among the studied cases were 43.1%, 40.7% and 16.3%, respectively, compared to 52.8%, 43.2% and 4.0%, respectively among the controls. For the MTRR A66G gene polymorphism, the genotypes frequencies of AA, AG and GG among the cases were 33.3%, 43.9% and 22.8%, respectively, while the frequencies were 49.6%, 42.4% and 8.0%, respectively, among control subjects. The frequencies for CC and CT genotypes of the MTHFR gene were 51.2% and 48.8%, respectively, in VSD patients compared to 56.8% and 43.2% respectively, in control subjects. Apart from MTHFR C677T polymorphism, significant differences were noticed (p < 0.05) in C524T and A66G polymorphisms of the MTRR gene between cases and control subjects. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Moldova, Republic of | 1 | 3% |
| United Kingdom | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 31 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 21% |
| Professor > Associate Professor | 4 | 12% |
| Student > Bachelor | 3 | 9% |
| Lecturer | 3 | 9% |
| Researcher | 3 | 9% |
| Other | 6 | 18% |
| Unknown | 8 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Medicine and Dentistry | 8 | 24% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Unspecified | 2 | 6% |
| Economics, Econometrics and Finance | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 9 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2013.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from International Journal of Molecular Sciences
#36,794
of 44,314 outputs
Outputs of similar age
#258,535
of 290,051 outputs
Outputs of similar age from International Journal of Molecular Sciences
#145
of 155 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 44,314 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.