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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Basophils are required for the induction of Th2 immunity to haptens and peptide antigens
|
|---|---|
| Published in |
Nature Communications, April 2013
|
| DOI | 10.1038/ncomms2740 |
| Pubmed ID | |
| Authors |
Atsushi Otsuka, Saeko Nakajima, Masato Kubo, Gyohei Egawa, Tetsuya Honda, Akihiko Kitoh, Takashi Nomura, Sho Hanakawa, Catharina Sagita Moniaga, Bongju Kim, Satoshi Matsuoka, Takeshi Watanabe, Yoshiki Miyachi, Kenji Kabashima |
| Abstract |
The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for Th2 skewing to haptens and peptide antigens, but not protein antigens in vivo. Consistent with this, basophils cannot take up or process ovalbumin protein in significant quantities, but present ovalbumin peptide to T cells for Th2 differentiation via major histocompatibility complex class II. Intriguingly, basophils promote Th2 skewing upon ovalbumin protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 80 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 23% |
| Student > Master | 11 | 13% |
| Student > Ph. D. Student | 10 | 12% |
| Student > Bachelor | 8 | 10% |
| Other | 7 | 9% |
| Other | 12 | 15% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 23% |
| Immunology and Microbiology | 18 | 22% |
| Medicine and Dentistry | 13 | 16% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 3 | 4% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2018.
All research outputs
#6,308,111
of 22,708,120 outputs
Outputs from Nature Communications
#34,515
of 46,738 outputs
Outputs of similar age
#53,239
of 195,118 outputs
Outputs of similar age from Nature Communications
#202
of 315 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 46,738 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,118 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 315 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.