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Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice

Overview of attention for article published in Microbiology and Immunology, April 2023
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Title
Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice
Published in
Microbiology and Immunology, April 2023
DOI 10.1111/1348-0421.13066
Pubmed ID
Authors

Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi

Abstract

Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B. pertussis, virulence-associated gene 8 (Vag8), causes coughing in combination with pertussis toxin and lipooligosaccharide. Here, we show that immunization with Vag8 protected mice from coughing after B. pertussis infection and enhanced the efficacy of a current pertussis vaccine containing pertussis toxoid against the cough. Our findings indicate that Vag8 could be a vaccine antigen to prevent pertussis cough. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 50%
Unknown 2 50%
Readers by discipline Count As %
Unspecified 2 50%
Unknown 2 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2023.
All research outputs
#14,683,430
of 23,511,526 outputs
Outputs from Microbiology and Immunology
#856
of 1,175 outputs
Outputs of similar age
#99,631
of 213,721 outputs
Outputs of similar age from Microbiology and Immunology
#2
of 9 outputs
Altmetric has tracked 23,511,526 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,175 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,721 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.