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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural basis of centromeric cohesion protection
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, April 2023
|
| DOI | 10.1038/s41594-023-00968-y |
| Pubmed ID | |
| Authors |
Alberto García-Nieto, Amrita Patel, Yan Li, Roel Oldenkamp, Leonardo Feletto, Joshua J. Graham, Laureen Willems, Kyle W. Muir, Daniel Panne, Benjamin D. Rowland |
| Abstract |
In the early stages of mitosis, cohesin is released from chromosome arms but not from centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid cohesion that resists the pulling forces of microtubules until all chromosomes are attached in a bipolar manner to the mitotic spindle. Here we present the X-ray crystal structure of a segment of human SGO1 bound to a conserved surface of the cohesin complex. SGO1 binds to a composite interface formed by the SA2 and SCC1RAD21 subunits of cohesin. SGO1 shares this binding interface with CTCF, indicating that these distinct chromosomal regulators control cohesin through a universal principle. This interaction is essential for the localization of SGO1 to centromeres and protects centromeric cohesin against WAPL-mediated cohesin release. SGO1-cohesin binding is maintained until the formation of microtubule-kinetochore attachments and is required for faithful chromosome segregation and the maintenance of a stable karyotype. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 16% |
| Netherlands | 1 | 3% |
| France | 1 | 3% |
| Italy | 1 | 3% |
| Unknown | 29 | 76% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 53% |
| Scientists | 16 | 42% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 30% |
| Researcher | 6 | 15% |
| Student > Bachelor | 4 | 10% |
| Professor | 2 | 5% |
| Other | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 13 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 50% |
| Agricultural and Biological Sciences | 3 | 8% |
| Chemistry | 2 | 5% |
| Medicine and Dentistry | 1 | 3% |
| Materials Science | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 295. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2023.
All research outputs
#126,431
of 26,533,029 outputs
Outputs from Nature Structural & Molecular Biology
#11
of 4,327 outputs
Outputs of similar age
#3,155
of 423,828 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#2
of 61 outputs
Altmetric has tracked 26,533,029 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,327 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.