Title |
Genome engineering of disease susceptibility genes for enhancing resistance in plants
|
---|---|
Published in |
Functional & Integrative Genomics, June 2023
|
DOI | 10.1007/s10142-023-01133-w |
Pubmed ID | |
Authors |
Ritika Bishnoi, Sehgeet Kaur, Jagdeep Singh Sandhu, Deepak Singla |
Abstract |
Introgression of disease resistance genes (R-genes) to fight against an array of phytopathogens takes several years using conventional breeding approaches. Pathogens develop mechanism(s) to escape plants immune system by evolving new strains/races, thus making them susceptible to disease. Conversely, disruption of host susceptibility factors (or S-genes) provides opportunities for resistance breeding in crops. S-genes are often exploited by phytopathogens to promote their growth and infection. Therefore, identification and targeting of disease susceptibility genes (S-genes) are gaining more attention for the acquisition of resistance in plants. Genome engineering of S-genes results in targeted, transgene-free gene modification through CRISPR-Cas-mediated technology and has been reported in several agriculturally important crops. In this review, we discuss the defense mechanism in plants against phytopathogens, tug of war between R-genes and S-genes, in silico techniques for identification of host-target (S-) genes and pathogen effector molecule(s), CRISPR-Cas-mediated S-gene engineering, its applications, challenges, and future prospects. |
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United States | 1 | 8% |
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Scientists | 4 | 33% |
Mendeley readers
Geographical breakdown
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Researcher | 3 | 12% |
Professor | 1 | 4% |
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Student > Bachelor | 1 | 4% |
Other | 1 | 4% |
Unknown | 14 | 56% |
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