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Unlocking the potential of microbiome editing: A review of conjugation‐based delivery

Overview of attention for article published in Molecular Microbiology, September 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 7,236)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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100 X users

Citations

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7 Dimensions

Readers on

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22 Mendeley
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Title
Unlocking the potential of microbiome editing: A review of conjugation‐based delivery
Published in
Molecular Microbiology, September 2023
DOI 10.1111/mmi.15147
Pubmed ID
Authors

Pedro Dorado‐Morales, Morgan Lambérioux, Didier Mazel

Abstract

In recent decades, there has been a rapid increase in the prevalence of multidrug-resistant pathogens, posing a challenge to modern antibiotic-based medicine. This has highlighted the need for novel treatments that can specifically affect the target microorganism without disturbing other co-inhabiting species, thus preventing the development of dysbiosis in treated patients. Moreover, there is a pressing demand for tools to effectively manipulate complex microbial populations. One of the approaches suggested to address both issues was to use conjugation as a tool to modify the microbiome by either editing the genome of specific bacterial species and/or the removal of certain taxonomic groups. Conjugation involves the transfer of DNA from one bacterium to another, which opens up the possibility of introducing, modifying or deleting specific genes in the recipient. In response to this proposal, there has been a significant increase in the number of studies using this method for gene delivery in bacterial populations. This MicroReview aims to provide a detailed overview on the use of conjugation for microbiome engineering, and at the same time, to initiate a discussion on the potential, limitations and possible future directions of this approach.

X Demographics

X Demographics

The data shown below were collected from the profiles of 100 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Researcher 4 18%
Student > Bachelor 2 9%
Professor 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 8 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 27%
Immunology and Microbiology 4 18%
Agricultural and Biological Sciences 2 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Engineering 1 5%
Other 0 0%
Unknown 8 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2023.
All research outputs
#834,721
of 26,369,714 outputs
Outputs from Molecular Microbiology
#20
of 7,236 outputs
Outputs of similar age
#15,256
of 364,205 outputs
Outputs of similar age from Molecular Microbiology
#1
of 40 outputs
Altmetric has tracked 26,369,714 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,236 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,205 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.