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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal
|
|---|---|
| Published in |
Cell Stem Cell, June 2013
|
| DOI | 10.1016/j.stem.2013.04.001 |
| Pubmed ID | |
| Authors |
Hiroko Morimoto, Kazumi Iwata, Narumi Ogonuki, Kimiko Inoue, Ogura Atsuo, Mito Kanatsu-Shinohara, Takeshi Morimoto, Chihiro Yabe-Nishimura, Takashi Shinohara |
| Abstract |
Reactive oxygen species (ROS) generation is implicated in stem cell self-renewal in several tissues but is thought to be detrimental for spermatogenesis as well as spermatogonial stem cells (SSCs). Using cultured SSCs, we show that ROS are generated via the AKT and MEK signaling pathways under conditions where the growth factors glial cell line-derived neurotrophic factor and fibroblast growth factor 2 drive SSC self-renewal and, instead, stimulate self-renewal at physiological levels. SSCs depleted of ROS stopped proliferating, but they showed enhanced self-renewal when ROS levels were increased by the addition of hydrogen peroxide, which induced the phosphorylation of stress kinases p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK). Moreover, ROS depletion in vivo decreased SSC number in the testis, and NADPH oxidase 1 (Nox1)-deficient SSCs exhibited reduced self-renewal division upon serial transplantation. These results suggest that ROS generated by Nox1 play critical roles in SSC self-renewal via the activation of the p38 MAPK and JNK pathways. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 5 | 33% |
| United States | 1 | 7% |
| Brazil | 1 | 7% |
| Germany | 1 | 7% |
| Australia | 1 | 7% |
| Unknown | 6 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 93% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 2% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| India | 1 | <1% |
| China | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 163 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 23% |
| Researcher | 36 | 21% |
| Student > Master | 21 | 12% |
| Professor > Associate Professor | 13 | 8% |
| Student > Doctoral Student | 9 | 5% |
| Other | 29 | 17% |
| Unknown | 23 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 40% |
| Biochemistry, Genetics and Molecular Biology | 45 | 26% |
| Medicine and Dentistry | 19 | 11% |
| Engineering | 4 | 2% |
| Neuroscience | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 25 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2014.
All research outputs
#3,765,352
of 25,371,288 outputs
Outputs from Cell Stem Cell
#1,665
of 2,823 outputs
Outputs of similar age
#31,395
of 206,489 outputs
Outputs of similar age from Cell Stem Cell
#31
of 54 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,489 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.