Title |
Adenovirus-induced hemorrhagic cystitis after CD19-targeted chimeric antigen receptor T-cell therapy in a patient with large B-cell lymphoma
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Published in |
Immunotherapy, September 2023
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DOI | 10.2217/imt-2023-0111 |
Pubmed ID | |
Authors |
Irene Medina, Cecilia Carpio, Isabel Ruiz-Camps, Adaia Albasanz-Puig, Oriana Lopez-Godino, Juliana Esperalba, Francisco Beas, Mario Sanchez-Salinas, Gloria Iacoboni, Pere Barba |
Abstract |
Chimeric antigen receptor (CAR) T cells targeting CD19 have changed the treatment landscape of patients with relapsed/refractory diffuse large B-cell lymphoma. Infections are one of the most frequent complications after CAR T-cell therapy. Most of these infections are bacterial, although viral infections can also occur in this setting. Adenovirus-induced hemorrhagic cystitis is a rare infectious complication and is usually observed after bone marrow or solid organ transplantation. Herein we report a case of adenovirus-induced hemorrhagic cystitis in a patient experiencing urinary symptoms within the first month after CAR T-cell infusion. Based on our experience and a literature review, we discuss the diagnostic approach and potential treatment options for this infrequent infection after CAR T-cell therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 7 | 47% |
Brazil | 1 | 7% |
United States | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 67% |
Practitioners (doctors, other healthcare professionals) | 5 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 1 | 33% |
Unknown | 2 | 67% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 1 | 33% |
Unknown | 2 | 67% |