Title |
A Mammalian Cell's Guide on How to Process a Bacteriophage
|
---|---|
Published in |
Annual Review of Virology, September 2023
|
DOI | 10.1146/annurev-virology-111821-111322 |
Pubmed ID | |
Authors |
Leo Kan, Jeremy J Barr |
Abstract |
Bacteriophages are enigmatic entities that defy definition. Classically, they are specialist viruses that exclusively parasitize bacterial hosts. Yet this definition becomes limiting when we consider their ubiquity in the body coupled with their vast capacity to directly interact with the mammalian host. While phages certainly do not infect nor replicate within mammalian cells, they do interact with and gain unfettered access to the eukaryotic cell structure. With the growing appreciation for the human virome, coupled with our increased application of phages to patients within clinical settings, the potential impact of phage-mammalian interactions is progressively recognized. In this review, we provide a detailed mechanistic overview of how phages interact with the mammalian cell surface, the processes through which said phages are internalized by the cell, and the intracellular processing and fate of the phages. We then summarize the current state-of-the-field with respect to phage-mammalian interactions and their associations with health and disease states. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 21% |
Australia | 8 | 15% |
United Kingdom | 5 | 9% |
Spain | 2 | 4% |
India | 2 | 4% |
Mexico | 2 | 4% |
Germany | 1 | 2% |
Switzerland | 1 | 2% |
Taiwan | 1 | 2% |
Other | 7 | 13% |
Unknown | 13 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 28 | 53% |
Members of the public | 22 | 42% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 39% |
Student > Ph. D. Student | 2 | 11% |
Professor | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Unspecified | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 17% |
Agricultural and Biological Sciences | 2 | 11% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Unspecified | 1 | 6% |
Chemical Engineering | 1 | 6% |
Other | 2 | 11% |
Unknown | 8 | 44% |