↓ Skip to main content

Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p–Pex21p

Overview of attention for article published in Nature Structural & Molecular Biology, June 2013
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
2 X users
facebook
1 Facebook page

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
73 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p–Pex21p
Published in
Nature Structural & Molecular Biology, June 2013
DOI 10.1038/nsmb.2618
Pubmed ID
Authors

Dongqing Pan, Toru Nakatsu, Hiroaki Kato

Abstract

Appropriate targeting of matrix proteins to peroxisomes is mainly directed by two types of peroxisomal targeting signals, PTS1 and PTS2. Although the basis of PTS1 recognition has been revealed by structural studies, that of PTS2 recognition remains elusive. Here we present the crystal structure of a heterotrimeric PTS2-recognition complex from Saccharomyces cerevisiae, containing Pex7p, the C-terminal region of Pex21p and the PTS2 of the peroxisomal 3-ketoacyl-CoA thiolase. Pex7p forms a β-propeller structure and provides a platform for cooperative interactions with both the amphipathic PTS2 helix and Pex21p. The C-terminal region of Pex21p directly covers the hydrophobic surfaces of both Pex7p and PTS2, and the resulting hydrophobic core is the primary determinant of stable complex formation. Together with in vivo and in vitro functional assays of Pex7p and Pex21p variants, our findings reveal the molecular mechanism of PTS2 recognition.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Netherlands 1 1%
Portugal 1 1%
Unknown 70 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 23%
Researcher 17 23%
Student > Bachelor 13 18%
Student > Master 4 5%
Professor 3 4%
Other 6 8%
Unknown 13 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 31 42%
Agricultural and Biological Sciences 24 33%
Chemistry 2 3%
Immunology and Microbiology 1 1%
Unspecified 1 1%
Other 0 0%
Unknown 14 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2013.
All research outputs
#16,721,208
of 25,373,627 outputs
Outputs from Nature Structural & Molecular Biology
#3,567
of 4,186 outputs
Outputs of similar age
#126,448
of 206,838 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#36
of 48 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.