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Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

Overview of attention for article published in Science, July 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

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1 blog
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27 X users
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5 patents
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2 Wikipedia pages
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1 research highlight platform

Citations

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469 Dimensions

Readers on

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390 Mendeley
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1 CiteULike
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Title
Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
Published in
Science, July 2013
DOI 10.1126/science.1236758
Pubmed ID
Authors

Jun Suzuki, Daniel P. Denning, Eiichi Imanishi, H. Robert Horvitz, Shigekazu Nagata

Abstract

A classic feature of apoptotic cells is the cell-surface exposure of phosphatidylserine (PtdSer) as an "eat me" signal for engulfment. We show that the Xk-family protein Xkr8 mediates PtdSer exposure in response to apoptotic stimuli. Mouse Xkr8(-/-) cells or human cancer cells in which Xkr8 expression was repressed by hypermethylation failed to expose PtdSer during apoptosis and were inefficiently engulfed by phagocytes. Xkr8 was activated directly by caspases and required a caspase-3 cleavage site for its function. CED-8, the only Caenorhabditis elegans Xk-family homolog, also promoted apoptotic PtdSer exposure and cell-corpse engulfment. Thus, Xk-family proteins have evolutionarily conserved roles in promoting the phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane.

X Demographics

X Demographics

The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 390 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Germany 1 <1%
Italy 1 <1%
United Kingdom 1 <1%
India 1 <1%
Japan 1 <1%
Canada 1 <1%
Unknown 380 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 99 25%
Student > Bachelor 50 13%
Researcher 47 12%
Student > Master 39 10%
Professor > Associate Professor 19 5%
Other 56 14%
Unknown 80 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 107 27%
Agricultural and Biological Sciences 102 26%
Medicine and Dentistry 27 7%
Immunology and Microbiology 25 6%
Neuroscience 16 4%
Other 34 9%
Unknown 79 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2024.
All research outputs
#1,235,327
of 26,378,648 outputs
Outputs from Science
#21,316
of 83,913 outputs
Outputs of similar age
#9,828
of 208,264 outputs
Outputs of similar age from Science
#236
of 836 outputs
Altmetric has tracked 26,378,648 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,913 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,264 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 836 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.