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DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions

Overview of attention for article published in Scientific Reports, July 2013
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Title
DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
Published in
Scientific Reports, July 2013
DOI 10.1038/srep02187
Pubmed ID
Authors

Tetsuro Komatsu, Takeshi Sekiya, Kyosuke Nagata

Abstract

The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Gambia 1 3%
Canada 1 3%
Unknown 32 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 29%
Student > Ph. D. Student 8 23%
Student > Master 5 14%
Student > Bachelor 4 11%
Student > Doctoral Student 2 6%
Other 0 0%
Unknown 6 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 34%
Biochemistry, Genetics and Molecular Biology 10 29%
Immunology and Microbiology 4 11%
Arts and Humanities 1 3%
Medicine and Dentistry 1 3%
Other 0 0%
Unknown 7 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2013.
All research outputs
#17,691,177
of 22,714,025 outputs
Outputs from Scientific Reports
#86,332
of 122,421 outputs
Outputs of similar age
#139,692
of 194,440 outputs
Outputs of similar age from Scientific Reports
#383
of 538 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 122,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,440 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 538 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.