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Antistress Effects of the Ethanolic Extract from Cymbopogon schoenanthus Growing Wild in Tunisia

Overview of attention for article published in Evidence-based Complementary & Alternative Medicine (eCAM), October 2013
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Title
Antistress Effects of the Ethanolic Extract from Cymbopogon schoenanthus Growing Wild in Tunisia
Published in
Evidence-based Complementary & Alternative Medicine (eCAM), October 2013
DOI 10.1155/2013/737401
Pubmed ID
Authors

Mahmoud Ben Othman, Junkyu Han, Abdelfatteh El Omri, Riadh Ksouri, Mohamed Neffati, Hiroko Isoda

Abstract

This study aimed to investigate the antistress properties of the ethanol extract of Cymbopogon schoenanthus (CSEE), growing wild in the southern part of Tunisia. The effect of extracts on H2O2-induced cytotoxicity and stress in human neuroblastoma SH-SY5Y cells. Its effect on stress-induced in ICR mice was exposed to force swim and tail suspension, in concordance with heat shock protein expression (HSP27 and HSP90), corticosterone, and catecholamine neurotransmitters level. Our results demonstrated that pretreatment of SH-SY5Y cells with CSEE at 1/2000, 1/1000, and 1/500 v/v dilutions significantly inversed H2O2-induced neurotoxicity. Moreover, CSEE treatments significantly reversed heat shock protein expression in heat-stressed HSP47-transformed cells (42°C, for 90 min) and mRNA expression of HSP27 and HSP90 in H2O2-treated SH-SY5Y. Daily oral administration of 100 mg/kg and 200 mg/kg CSEE was conducted to ICR mice for 2 weeks. It was resulted in a significant decrease of immobility time in forced swimming and tail suspension tests. The effect of CSEE on animal behavior was concordant with a significant regulation of blood serum corticosterone and cerebral cortex levels of catecholamine (dopamine, adrenaline, and noradrenaline). Therefore, this study was attempted to demonstrate the preventive potential of CSEE against stress disorders at in vitro and in vivo levels.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Algeria 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 11%
Professor > Associate Professor 4 11%
Student > Master 3 8%
Lecturer 2 5%
Student > Postgraduate 2 5%
Other 8 21%
Unknown 15 39%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 16%
Biochemistry, Genetics and Molecular Biology 5 13%
Medicine and Dentistry 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Sports and Recreations 1 3%
Other 3 8%
Unknown 18 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2013.
All research outputs
#23,291,671
of 25,956,379 outputs
Outputs from Evidence-based Complementary & Alternative Medicine (eCAM)
#6,566
of 9,364 outputs
Outputs of similar age
#199,082
of 224,135 outputs
Outputs of similar age from Evidence-based Complementary & Alternative Medicine (eCAM)
#164
of 230 outputs
Altmetric has tracked 25,956,379 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,364 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,135 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 230 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.