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Involvement of Fcα/μR (CD351) in autoantibody production

Overview of attention for article published in Molecular Immunology, October 2013
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1 Wikipedia page

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4 Dimensions

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19 Mendeley
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Title
Involvement of Fcα/μR (CD351) in autoantibody production
Published in
Molecular Immunology, October 2013
DOI 10.1016/j.molimm.2013.10.002
Pubmed ID
Authors

Yuichi Yoshizawa, Shin-ichiro Honda, Akira Shibuya

Abstract

Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 4 21%
Researcher 3 16%
Student > Master 2 11%
Student > Ph. D. Student 1 5%
Lecturer 1 5%
Other 2 11%
Unknown 6 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 26%
Immunology and Microbiology 4 21%
Biochemistry, Genetics and Molecular Biology 2 11%
Medicine and Dentistry 1 5%
Chemistry 1 5%
Other 0 0%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2019.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Molecular Immunology
#1,249
of 3,885 outputs
Outputs of similar age
#76,556
of 225,378 outputs
Outputs of similar age from Molecular Immunology
#11
of 29 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,885 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,378 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.