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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts
|
|---|---|
| Published in |
Scientific Reports, January 2014
|
| DOI | 10.1038/srep03843 |
| Pubmed ID | |
| Authors |
Ganesh N. Pandian, Junichi Taniguchi, Syed Junetha, Shinsuke Sato, Le Han, Abhijit Saha, Chandran AnandhaKumar, Toshikazu Bando, Hiroki Nagase, Thangavel Vaijayanthi, Rhys D. Taylor, Hiroshi Sugiyama |
| Abstract |
The influential role of the epigenome in orchestrating genome-wide transcriptional activation instigates the demand for the artificial genetic switches with distinct DNA sequence recognition. Recently, we developed a novel class of epigenetically active small molecules called SAHA-PIPs by conjugating selective DNA binding pyrrole-imidazole polyamides (PIPs) with the histone deacetylase inhibitor SAHA. Screening studies revealed that certain SAHA-PIPs trigger targeted transcriptional activation of pluripotency and germ cell genes in mouse and human fibroblasts, respectively. Through microarray studies and functional analysis, here we demonstrate for the first time the remarkable ability of thirty-two different SAHA-PIPs to trigger the transcriptional activation of exclusive clusters of genes and noncoding RNAs. QRT-PCR validated the microarray data, and some SAHA-PIPs activated therapeutically significant genes like KSR2. Based on the aforementioned results, we propose the potential use of SAHA-PIPs as reagents capable of targeted transcriptional activation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 7 | 37% |
| France | 1 | 5% |
| Italy | 1 | 5% |
| United States | 1 | 5% |
| Unknown | 9 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 84% |
| Scientists | 3 | 16% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 67 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 15% |
| Student > Ph. D. Student | 10 | 14% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Other | 18 | 25% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 27% |
| Biochemistry, Genetics and Molecular Biology | 16 | 23% |
| Medicine and Dentistry | 10 | 14% |
| Chemistry | 8 | 11% |
| Computer Science | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 10 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#2,729,007
of 25,002,811 outputs
Outputs from Scientific Reports
#23,675
of 137,164 outputs
Outputs of similar age
#31,608
of 318,883 outputs
Outputs of similar age from Scientific Reports
#133
of 723 outputs
Altmetric has tracked 25,002,811 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 137,164 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 723 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.