Title |
Critical roles of nardilysin in the maintenance of body temperature homoeostasis
|
---|---|
Published in |
Nature Communications, February 2014
|
DOI | 10.1038/ncomms4224 |
Pubmed ID | |
Authors |
Yoshinori Hiraoka, Tatsuhiko Matsuoka, Mikiko Ohno, Kazuhiro Nakamura, Sayaka Saijo, Shigenobu Matsumura, Kiyoto Nishi, Jiro Sakamoto, Po-Min Chen, Kazuo Inoue, Tohru Fushiki, Toru Kita, Takeshi Kimura, Eiichiro Nishi |
Abstract |
Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis. Nrd1(-/-) mice show increased energy expenditure owing to enhanced BAT thermogenesis and hyperactivity. Despite these findings, Nrd1(-/-) mice show hypothermia and cold intolerance that are attributed to the lowered set point of body temperature, poor insulation and impaired cold-induced thermogenesis. Induction of β3-adrenergic receptor, PGC-1α and UCP1 in response to cold is severely impaired in the absence of NRDc. At the molecular level, NRDc and PGC-1α interact and co-localize at the UCP1 enhancer, where NRDc represses PGC-1α activity. These findings reveal a novel nuclear function of NRDc and provide important insights into the mechanism of thermoregulation. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 11% |
Unknown | 8 | 89% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 89% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
India | 1 | 2% |
Unknown | 64 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 27% |
Student > Ph. D. Student | 15 | 23% |
Other | 5 | 8% |
Student > Master | 4 | 6% |
Student > Bachelor | 4 | 6% |
Other | 9 | 14% |
Unknown | 11 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 27% |
Medicine and Dentistry | 11 | 17% |
Biochemistry, Genetics and Molecular Biology | 11 | 17% |
Neuroscience | 3 | 5% |
Chemistry | 3 | 5% |
Other | 7 | 11% |
Unknown | 13 | 20% |