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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
|
|---|---|
| Published in |
Nature Genetics, June 2017
|
| DOI | 10.1038/ng.3888 |
| Pubmed ID | |
| Authors |
Anke R Hammerschlag, Sven Stringer, Christiaan A de Leeuw, Suzanne Sniekers, Erdogan Taskesen, Kyoko Watanabe, Tessa F Blanken, Kim Dekker, Bart H W te Lindert, Rick Wassing, Ingileif Jonsdottir, Gudmar Thorleifsson, Hreinn Stefansson, Thorarinn Gislason, Klaus Berger, Barbara Schormair, Juergen Wellmann, Juliane Winkelmann, Kari Stefansson, Konrad Oexle, Eus J W Van Someren, Danielle Posthuma |
| Abstract |
Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10(-8)) has previously been implicated in restless legs syndrome (RLS). Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. Sex-specific analyses suggest that there are different genetic architectures between the sexes in addition to shared genetic factors. We show substantial positive genetic correlation of insomnia complaints with internalizing personality traits and metabolic traits and negative correlation with subjective well-being and educational attainment. These findings provide new insight into the genetic architecture of insomnia. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 14% |
| United Kingdom | 7 | 5% |
| Saudi Arabia | 7 | 5% |
| Netherlands | 5 | 3% |
| Australia | 3 | 2% |
| Canada | 2 | 1% |
| Denmark | 1 | <1% |
| Croatia | 1 | <1% |
| South Africa | 1 | <1% |
| Other | 6 | 4% |
| Unknown | 98 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 86 | 56% |
| Scientists | 50 | 33% |
| Practitioners (doctors, other healthcare professionals) | 13 | 8% |
| Science communicators (journalists, bloggers, editors) | 4 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 334 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 333 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 20% |
| Researcher | 61 | 18% |
| Student > Master | 35 | 10% |
| Student > Bachelor | 25 | 7% |
| Other | 16 | 5% |
| Other | 55 | 16% |
| Unknown | 75 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 16% |
| Agricultural and Biological Sciences | 44 | 13% |
| Biochemistry, Genetics and Molecular Biology | 40 | 12% |
| Neuroscience | 35 | 10% |
| Psychology | 35 | 10% |
| Other | 35 | 10% |
| Unknown | 91 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 738. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2024.
All research outputs
#28,967
of 26,512,081 outputs
Outputs from Nature Genetics
#43
of 7,748 outputs
Outputs of similar age
#510
of 337,385 outputs
Outputs of similar age from Nature Genetics
#2
of 74 outputs
Altmetric has tracked 26,512,081 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,748 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,385 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.