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Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome

Overview of attention for article published in International Journal of Cardiology, June 2017
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Title
Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome
Published in
International Journal of Cardiology, June 2017
DOI 10.1016/j.ijcard.2017.06.107
Pubmed ID
Authors

Dejana Popovic, Dejana Martic, Tea Djordjevic, Vesna Pesic, Marco Guazzi, Jonathan Myers, Reza Mohebi, Ross Arena

Abstract

Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. 40 Caucasian patients (21.2% females), mean age 63.5±7.6 with significant coronary artery lesions (≥50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4days apart; subjects were subsequently followed 32±10months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Mean ejection fraction was 56.7±9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (∆VCO2) recovery/peak (area under ROC curve 0.77, p=0.02, Sn=87.5%, Sp=70.4%) and oxygen uptake (∆VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p=0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted ΔWMSI peak/rest on univariate analysis (p<0.05). Multivariate Cox analysis revealed a high predictive value of ∆VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR=1.27, CI=1.07-1.51, p=0.008). The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 13%
Student > Master 5 13%
Student > Bachelor 3 8%
Student > Doctoral Student 3 8%
Lecturer 2 5%
Other 8 21%
Unknown 12 32%
Readers by discipline Count As %
Medicine and Dentistry 12 32%
Nursing and Health Professions 4 11%
Computer Science 2 5%
Psychology 2 5%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 16 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2019.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from International Journal of Cardiology
#3,854
of 7,535 outputs
Outputs of similar age
#171,883
of 328,389 outputs
Outputs of similar age from International Journal of Cardiology
#47
of 118 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,535 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,389 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.