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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data
|
|---|---|
| Published in |
Cell Reports, August 2014
|
| DOI | 10.1016/j.celrep.2014.07.021 |
| Pubmed ID | |
| Authors |
Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda |
| Abstract |
Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored. We have developed a reconstruction method for the signal flow based on time-course phosphoproteome and metabolome data, using multiple databases, and have applied it to acute action of insulin, an important hormone for metabolic homeostasis. An insulin signal flows through a network, through signaling pathways that involve 13 protein kinases, 26 phosphorylated metabolic enzymes, and 35 allosteric effectors, resulting in quantitative changes in 44 metabolites. Analysis of the network reveals that insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, thereby controlling a key reaction in glycolysis. We thus provide a versatile method of reconstruction of signal flow through the network using phosphoproteome and metabolome data. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 18% |
| Germany | 1 | 6% |
| United States | 1 | 6% |
| Unknown | 12 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 82% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 4 | 2% |
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Australia | 1 | <1% |
| Belgium | 1 | <1% |
| Switzerland | 1 | <1% |
| China | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 244 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 58 | 23% |
| Student > Ph. D. Student | 45 | 18% |
| Student > Master | 35 | 14% |
| Student > Bachelor | 32 | 12% |
| Professor > Associate Professor | 16 | 6% |
| Other | 41 | 16% |
| Unknown | 30 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 77 | 30% |
| Biochemistry, Genetics and Molecular Biology | 73 | 28% |
| Medicine and Dentistry | 19 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Engineering | 8 | 3% |
| Other | 29 | 11% |
| Unknown | 42 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2021.
All research outputs
#3,377,843
of 25,397,764 outputs
Outputs from Cell Reports
#6,688
of 12,990 outputs
Outputs of similar age
#33,052
of 243,727 outputs
Outputs of similar age from Cell Reports
#80
of 178 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,990 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,727 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.