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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protective effect of SENP3-mediated SUMOylation against cadmium toxicity
|
|---|---|
| Published in |
Journal of Toxicological Sciences, January 2017
|
| DOI | 10.2131/jts.42.233 |
| Pubmed ID | |
| Authors |
Hongquan Zhu |
| Abstract |
SUMOylation is widely reported as a cytoprotective response against cell stress induced by ischemia and reperfusion. However, it is still unclear what other cell stressors trigger protein SUMOylation, what mechanisms enhance and maintain the enhanced SUMOylation, and if it is a general protective mediator against other cytotoxic stresses, toxic heavy metal cadmium for instance. Here, we show increased levels of SUMOylation and decreased levels of the deSUMOylation enzyme SENP3 in PC12 cells exposed to CdCl2. In addition, SENP3 knockdown reduced cadmium-induced apoptosis and cell death in PC12 cells, while SENP3 overexpression enhanced cell death. These results suggest that SENP3 is an important regulator of the cell response to cadmium stress. Our finding is consistent with previous reports of SENP3 and SUMOylation in ischemia, and implies that the regulation of SENP3 levels and subsequent changes in SUMOylation could be a general cytoprotective mechanism. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Lecturer | 1 | 50% |
| Other | 1 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 50% |
| Unknown | 1 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2017.
All research outputs
#23,195,360
of 25,850,671 outputs
Outputs from Journal of Toxicological Sciences
#483
of 581 outputs
Outputs of similar age
#365,651
of 424,449 outputs
Outputs of similar age from Journal of Toxicological Sciences
#21
of 29 outputs
Altmetric has tracked 25,850,671 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 581 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.