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The Impact of Autophagy on Cardiovascular Senescence and Diseases

Overview of attention for article published in International Heart Journal, September 2017
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Title
The Impact of Autophagy on Cardiovascular Senescence and Diseases
Published in
International Heart Journal, September 2017
DOI 10.1536/ihj.17-246
Pubmed ID
Authors

Yuichi Sasaki, Yoshiyuki Ikeda, Masaaki Iwabayashi, Yuichi Akasaki, Mitsuru Ohishi

Abstract

The risk of cardiovascular disease increases with age, causing chronic disability, morbidity, and mortality in the elderly. Cardiovascular aging and disease are characterized by heart failure, cardiac ischemia-reperfusion injury, cardiomyopathy, hypertension, arterial stiffness, and atherosclerosis. As a cell ages, damaged organelles and abnormal proteins accumulate. A system for removing these cytoplasmic substrates is essential for maintaining homeostasis. Autophagy assists tissue homeostasis by forming a pathway by which these substances are degraded. Growing evidence suggests that autophagy plays a role in age-related and disease states of the cardiovascular system, and it may even be effective in preventing or treating cardiovascular disease. On the other hand, overexpression of autophagy in the heart and arteries can produce detrimental effects. We summarize the current understanding of the close relationship between autophagy and cardiovascular senescence.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Student > Bachelor 6 13%
Student > Ph. D. Student 5 10%
Researcher 4 8%
Other 4 8%
Other 10 21%
Unknown 11 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 21%
Medicine and Dentistry 9 19%
Agricultural and Biological Sciences 5 10%
Unspecified 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 5 10%
Unknown 14 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2019.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from International Heart Journal
#539
of 714 outputs
Outputs of similar age
#290,468
of 330,567 outputs
Outputs of similar age from International Heart Journal
#4
of 7 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 714 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,567 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.