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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Simple knockout by electroporation of engineered endonucleases into intact rat embryos
|
|---|---|
| Published in |
Scientific Reports, October 2014
|
| DOI | 10.1038/srep06382 |
| Pubmed ID | |
| Authors |
Takehito Kaneko, Tetsushi Sakuma, Takashi Yamamoto, Tomoji Mashimo |
| Abstract |
Engineered endonucleases, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system, provide a powerful approach for genome editing in animals. However, the microinjection of endonucleases into embryos requires a high skill level, is time consuming, and may cause damage to embryos. Here, we demonstrate that the electroporation of endonuclease mRNAs into intact embryos can induce editing at targeted loci and efficiently produce knockout rats. It is noteworthy that the electroporation of ZFNs resulted in an embryonic survival rate (91%) and a genome-editing rate (73%) that were more than 2-fold higher than the corresponding rates from conventional microinjection. Electroporation technology provides a simple and effective method to produce knockout animals. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 17% |
| Japan | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 1 | <1% |
| India | 1 | <1% |
| Unknown | 206 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 18% |
| Student > Ph. D. Student | 33 | 16% |
| Student > Master | 19 | 9% |
| Student > Bachelor | 19 | 9% |
| Professor > Associate Professor | 15 | 7% |
| Other | 35 | 17% |
| Unknown | 51 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 26% |
| Biochemistry, Genetics and Molecular Biology | 53 | 25% |
| Engineering | 11 | 5% |
| Medicine and Dentistry | 7 | 3% |
| Neuroscience | 6 | 3% |
| Other | 20 | 10% |
| Unknown | 58 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#1,963,289
of 25,801,916 outputs
Outputs from Scientific Reports
#18,016
of 143,092 outputs
Outputs of similar age
#21,084
of 266,526 outputs
Outputs of similar age from Scientific Reports
#82
of 748 outputs
Altmetric has tracked 25,801,916 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 143,092 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 748 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.