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Mendeley readers
Attention Score in Context
| Title |
Effect of Cepharanthin on the lethality and cardiovascular disorder by Mamushi, Agkistrodon halys blomhoffii, snake venom
|
|---|---|
| Published in |
Folia Pharmacologica Japonica, January 1991
|
| DOI | 10.1254/fpj.98.5_327 |
| Pubmed ID | |
| Authors |
T Abe, S Inamura, M Akasu |
| Abstract |
Effects of Cephranthin on the lethality to mice and the cardiovascular disorder in rat induced by Mamushi (Agkistrodon halys blomhoffi) snake venom were studied. The LD50 of Mamushi snake venom was 1.22 mg/kg in mice by i.p. administration. Cepharanthin activated slightly the lethal activity when it was administered just after injection of the venom. However, this drug was effective against the venom at 4 to 5 times the lethal dose, if it was administered at the optimal interval. Mamushi snake venom and Cepharanthin showed a lethality and dose relationship that were clearly prolonged by Cepharanthin. In rat, Mamushi snake venom administered intraperitoneally produced an irreversible decrease of blood pressure accompanied by capillary hemorrhage. Moreover, it suppressed the heart rate. On the electrocardiogram, prolongation of ventricular contraction, extension of the relative refractory period and reduction of diastole were induced by the venom. These observations show that the venom suppresses cardiac functions inotropically and chronotropically. Cepharanthin shortened the refractory period and prolonged the diastole, indicating that it activated cardiac function. It was able to produce recovery from several cardiac disorders induced by Mamushi snake venom, for example, increase of blood pressure with inhibition of capillary hemorrage, release of heart rate suppression, partial recovery of the amplitudes of P and R waves, and shortening of extensive relative refractory period. These cardiac recoveries by Cepharanthin will be reflected in the suppression of lethality. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2022.
All research outputs
#7,585,485
of 24,396,012 outputs
Outputs from Folia Pharmacologica Japonica
#183
of 792 outputs
Outputs of similar age
#12,182
of 62,091 outputs
Outputs of similar age from Folia Pharmacologica Japonica
#4
of 9 outputs
Altmetric has tracked 24,396,012 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 792 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,091 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.