Title |
Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma
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Published in |
BMC Immunology, May 2008
|
DOI | 10.1186/1471-2172-9-22 |
Pubmed ID | |
Authors |
Zorica Juranic, Jelena Radic, Aleksandra Konic-Ristic, Svetislav Jelic, Biljana Mihaljevic, Ivan Stankovic, Suzana Matkovic, Irina Besu, Dušica Gavrilović |
Abstract |
Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen.Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. |
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