The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Mendeley readers
Attention Score in Context
| Title |
Retention of Multilineage Differentiation Potential of Mesenchymal Cells during Proliferation in Response to FGF
|
|---|---|
| Published in |
Biochemical & Biophysical Research Communications, October 2001
|
| DOI | 10.1006/bbrc.2001.5777 |
| Pubmed ID | |
| Authors |
Shinichi Tsutsumi, Atsushi Shimazu, Kazuko Miyazaki, Haiou Pan, Chika Koike, Eri Yoshida, Kenji Takagishi, Yukio Kato |
| Abstract |
Mesenchymal stem cells (MSC) that can differentiate to various connective tissue cells may be useful for autologous cell transplantation to defects of bone, cartilage, and tendon, if MSC can be expanded in vitro. However, a short life span of MSC and a reduction in their differentiation potential in culture have limited their clinical application. The purpose of this study is to identify a growth factor(s) involved in self-renewal of MSC and the maintenance of their multilineage differentiation potential. Fibroblast growth factor-2 (FGF-2) markedly increased the growth rate and the life span of rabbit, canine, and human bone marrow MSC in monolayer cultures. This effect of FGF-2 was more prominent in low-density cultures than in high-density cultures. In addition, all MSC expanded in vitro with FGF-2, but not without FGF-2, differentiated to chondrocytes in pellet cultures. The FGF+ MSC also retained the osteogenic and adipogenic potential throughout many mitotic divisions. These findings suggest that FGFs play a crucial role in self-renewal of MSC. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| France | 3 | 1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Switzerland | 1 | <1% |
| Sweden | 1 | <1% |
| Czechia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Other | 4 | 2% |
| Unknown | 204 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 18% |
| Researcher | 38 | 17% |
| Student > Master | 33 | 15% |
| Student > Bachelor | 17 | 8% |
| Student > Doctoral Student | 16 | 7% |
| Other | 38 | 17% |
| Unknown | 41 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 25% |
| Medicine and Dentistry | 39 | 18% |
| Biochemistry, Genetics and Molecular Biology | 35 | 16% |
| Engineering | 19 | 9% |
| Materials Science | 7 | 3% |
| Other | 23 | 10% |
| Unknown | 44 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2014.
All research outputs
#5,718,170
of 26,316,305 outputs
Outputs from Biochemical & Biophysical Research Communications
#3,151
of 26,887 outputs
Outputs of similar age
#7,737
of 45,257 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#17
of 201 outputs
Altmetric has tracked 26,316,305 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,887 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 45,257 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.