You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry, March 2015
|
| DOI | 10.1016/j.bmc.2015.02.061 |
| Pubmed ID | |
| Authors |
Igor M. Opsenica, Tatjana Ž. Verbić, Mikloš Tot, Richard J. Sciotti, Brandon S. Pybus, Olgica Djurković-Djaković, Ksenija Slavić, Bogdan A. Šolaja |
| Abstract |
We herein report the design and synthesis of a novel series of thiophene- and furan-based aminoquinoline derivatives which were found to be potent antimalarials and inhibitors of β-hematin polymerization. Tested compounds were 3-71 times more potent in vitro than CQ against chloroquine-resistant (CQR) W2 strain with benzonitrile 30 being as active as mefloquine (MFQ), and almost all synthesized aminoquinolines (22/27) were more potent than MFQ against multidrug-resistant (MDR) strain C235. In vivo experiments revealed that compound 28 showed clearance with recrudescence at 40mg/kg/day, while 5/5 mice survived in Thompson test at 160mg/kg/day. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 9% |
| United States | 1 | 4% |
| Unknown | 20 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 17% |
| Student > Ph. D. Student | 4 | 17% |
| Other | 3 | 13% |
| Researcher | 3 | 13% |
| Lecturer | 2 | 9% |
| Other | 3 | 13% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 22% |
| Chemistry | 4 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
| Immunology and Microbiology | 2 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 5 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2015.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Bioorganic & Medicinal Chemistry
#6,341
of 7,493 outputs
Outputs of similar age
#165,682
of 273,966 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry
#80
of 110 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,493 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.