Title |
Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)
|
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Published in |
Journal of Endocrinology, July 1991
|
DOI | 10.1677/joe.0.1300087 |
Pubmed ID | |
Authors |
S D McCormick, T Sakamoto, S Hasegawa, T Hirano |
Abstract |
The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0.2 micrograms/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0.01, 0.05 and 0.02 micrograms/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0.01, 0.05 and 0.2 micrograms/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater adaptation of salmonids. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 14% |
Student > Ph. D. Student | 3 | 14% |
Professor | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Researcher | 2 | 9% |
Other | 4 | 18% |
Unknown | 6 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 50% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Environmental Science | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Neuroscience | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 23% |