Title |
Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells
|
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Published in |
Journal of Veterinary Medical Science, July 2015
|
DOI | 10.1292/jvms.15-0245 |
Pubmed ID | |
Authors |
Shingo ISHIKAWA, Hiroshi TAKEMITSU, Makoto HABARA, MORI Nobuko, Ichiro YAMAMOTO, ARAI Toshiro |
Abstract |
Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 50% |
Researcher | 2 | 33% |
Student > Doctoral Student | 1 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 33% |
Veterinary Science and Veterinary Medicine | 1 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Medicine and Dentistry | 1 | 17% |
Unknown | 1 | 17% |