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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanoma
|
|---|---|
| Published in |
International Immunology, September 2015
|
| DOI | 10.1093/intimm/dxv053 |
| Pubmed ID | |
| Authors |
Ivan Stanojevic, Karolina Miller, Lidija Kandolf-Sekulovic, Zeljko Mijuskovic, Lidija Zolotarevski, Milena Jovic, Milomir Gacevic, Mirjana Djukic, Nebojsa Arsenijevic, Danilo Vojvodic |
| Abstract |
Seventy-eight melanoma patients and ten healthy individuals were examined. Follow up examinations of all melanoma patients were performed regularly on three months. Myeloid-derived suppressor cells (MDSC) were defined as lineage negative (CD3-, CD19-, CD56-), HLA-DR-/low, CD11b+ and CD33+. Classification of granulocytic (GrMDSC) and monocytic (MoMDSC) subsets was based on the CD15 and CD14 expression, respectively. Unlike the MoMDSC, that were present in 60% of healthy controls and 15% of melanoma patients, the GrMDSC were present in all examined participants, and the melanoma patients were found to have statistically higher frequencies compared with healthy controls. Accordingly, we kept focused on GrMDSC frequencies in relation to the melanoma stages and course of the disease. The GrMDSC values are highest in stage IV melanoma patients, with statistical significance compared to stages IA, IB, IIA, and IIB. Patients with progression had statistically higher GrMDSC counts comparing with those with stable disease (p=0.0079). Patients who had progression free interval (PFI)<12 months showed significantly higher GrMDSC values compared to those with PFI>12 months (p=0.0333). Granulocytic MDSC showed significant negative correlation with PFI intervals (p=0.0095). The granulocytic MDSC subset was predominant in all our patients. We confirmed that GrMDSC do accumulate early in the peripheral blood of melanoma patients and their frequencies correlate narrowly with the clinical stage and the spread of the disease. Increase in GrMDSC frequencies correlates well with a progressive disease and could be considered as a potential predictive biomarker of high risk melanoma cases that are more likely to have a shorter PFI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 4% |
| Unknown | 23 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 25% |
| Professor | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Doctoral Student | 3 | 13% |
| Librarian | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 5 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 17% |
| Medicine and Dentistry | 4 | 17% |
| Agricultural and Biological Sciences | 3 | 13% |
| Immunology and Microbiology | 3 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Other | 1 | 4% |
| Unknown | 7 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2019.
All research outputs
#2,760,551
of 25,377,790 outputs
Outputs from International Immunology
#56
of 1,944 outputs
Outputs of similar age
#36,471
of 285,679 outputs
Outputs of similar age from International Immunology
#2
of 16 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,944 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.