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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells
|
|---|---|
| Published in |
Stem Cell Reports, February 2016
|
| DOI | 10.1016/j.stemcr.2016.01.005 |
| Pubmed ID | |
| Authors |
Shuichi Kitayama, Rong Zhang, Tian-Yi Liu, Norihiro Ueda, Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Minako Tatsumi, Norihito Hirai, Yasutaka Mizoro, Tatsuaki Iwama, Akira Watanabe, Mahito Nakanishi, Kiyotaka Kuzushima, Yasushi Uemura, Shin Kaneko |
| Abstract |
Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptive immune responses, which enhance effective immunity against cancer. Conversely, reduced iNKT cell numbers and function have been observed in many patients with cancer. To recover these numbers, we reprogrammed human iNKT cells to pluripotency and then re-differentiated them into regenerated iNKT cells in vitro through an IL-7/IL-15-based optimized cytokine combination. The re-differentiated iNKT cells showed proliferation and IFN-γ production in response to α-galactosylceramide, induced dendritic cell maturation and downstream activation of both cytotoxic T lymphocytes and NK cells, and exhibited NKG2D- and DNAM-1-mediated NK cell-like cytotoxicity against cancer cell lines. The immunological features of re-differentiated iNKT cells and their unlimited availability from induced pluripotent stem cells offer a potentially effective immunotherapy against cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 21% |
| China | 1 | 7% |
| France | 1 | 7% |
| United Kingdom | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 7 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 86% |
| Science communicators (journalists, bloggers, editors) | 2 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| Switzerland | 1 | 1% |
| Unknown | 86 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Researcher | 13 | 15% |
| Other | 10 | 11% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Other | 13 | 15% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 21% |
| Immunology and Microbiology | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Medicine and Dentistry | 10 | 11% |
| Engineering | 2 | 2% |
| Other | 9 | 10% |
| Unknown | 20 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2022.
All research outputs
#1,118,289
of 25,374,647 outputs
Outputs from Stem Cell Reports
#354
of 2,142 outputs
Outputs of similar age
#20,435
of 409,554 outputs
Outputs of similar age from Stem Cell Reports
#9
of 43 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,142 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 409,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.