Title |
Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
|
---|---|
Published in |
PLOS ONE, February 2012
|
DOI | 10.1371/journal.pone.0031317 |
Pubmed ID | |
Authors |
Young-il Kim, Shizuka Hirai, Tsuyoshi Goto, Chie Ohyane, Haruya Takahashi, Taneaki Tsugane, Chiaki Konishi, Takashi Fujii, Shuji Inai, Yoko Iijima, Koh Aoki, Daisuke Shibata, Nobuyuki Takahashi, Teruo Kawada |
Abstract |
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 123 | 40% |
United States | 7 | 2% |
Taiwan | 2 | <1% |
Austria | 1 | <1% |
Timor-Leste | 1 | <1% |
Unknown | 171 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 298 | 98% |
Scientists | 4 | 1% |
Science communicators (journalists, bloggers, editors) | 2 | <1% |
Practitioners (doctors, other healthcare professionals) | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 9 | 7% |
United States | 2 | 1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
France | 1 | <1% |
Unknown | 122 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 22% |
Student > Ph. D. Student | 19 | 14% |
Professor > Associate Professor | 15 | 11% |
Student > Master | 14 | 10% |
Student > Bachelor | 13 | 10% |
Other | 25 | 18% |
Unknown | 20 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 60 | 44% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Medicine and Dentistry | 13 | 10% |
Chemistry | 5 | 4% |
Sports and Recreations | 4 | 3% |
Other | 13 | 10% |
Unknown | 26 | 19% |