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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0031317 |
| Pubmed ID | |
| Authors |
Young-il Kim, Shizuka Hirai, Tsuyoshi Goto, Chie Ohyane, Haruya Takahashi, Taneaki Tsugane, Chiaki Konishi, Takashi Fujii, Shuji Inai, Yoko Iijima, Koh Aoki, Daisuke Shibata, Nobuyuki Takahashi, Teruo Kawada |
| Abstract |
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 123 | 40% |
| United States | 7 | 2% |
| Taiwan | 2 | <1% |
| Austria | 1 | <1% |
| Timor-Leste | 1 | <1% |
| Unknown | 171 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 298 | 98% |
| Scientists | 4 | 1% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
| Practitioners (doctors, other healthcare professionals) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 9 | 7% |
| United States | 2 | 1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| France | 1 | <1% |
| Unknown | 122 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 22% |
| Student > Ph. D. Student | 19 | 14% |
| Professor > Associate Professor | 15 | 11% |
| Student > Master | 14 | 10% |
| Student > Bachelor | 13 | 10% |
| Other | 25 | 18% |
| Unknown | 20 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 60 | 44% |
| Biochemistry, Genetics and Molecular Biology | 15 | 11% |
| Medicine and Dentistry | 13 | 10% |
| Chemistry | 5 | 4% |
| Sports and Recreations | 4 | 3% |
| Other | 13 | 10% |
| Unknown | 26 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 268. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#144,362
of 26,580,681 outputs
Outputs from PLOS ONE
#2,194
of 231,935 outputs
Outputs of similar age
#620
of 258,324 outputs
Outputs of similar age from PLOS ONE
#22
of 3,384 outputs
Altmetric has tracked 26,580,681 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 231,935 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,324 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 3,384 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.