Title |
Comparison of the effects of long-term pimobendan and benazepril administration in normal cats
|
---|---|
Published in |
Journal of Veterinary Medical Science, March 2016
|
DOI | 10.1292/jvms.14-0673 |
Pubmed ID | |
Authors |
Yuichi MIYAGAWA, Noboru MACHIDA, TODA Noriko, Yoshinori TOMINAGA, Naoyuki TAKEMURA |
Abstract |
Pimobendan (PIMO) can cause adverse effects, such as mitral valve degeneration, in dogs; however, it is unclear whether these effects occur in cats. Therefore, we aimed to determine whether PIMO or benazepril produces adverse cardiac effects in healthy cats. This was a blinded, randomized, prospective parallel study. Twelve cats were randomly divided into two groups of six cats, namely, an angiotensin-converting-enzyme inhibitor group that received benazepril and a PIMO group. Cats were administered their respective treatments for 506 days, and we evaluated cardiac parameters, blood biochemistry and glomerular filtration rates during that time. At the end of the trial, the cats were euthanized, and histopathological examinations were performed by a pathologist who was blinded to the treatment groups. No significant changes were observed in any of the parameters measured in either of the groups. In particular, no significant cardiac lesions were observed in either of the groups. In healthy cats, neither PIMO nor benazepril appears to cause cardiac lesions, but future studies are needed to examine the effects of PIMO in cats with heart disease. |
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Country | Count | As % |
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Unknown | 2 | 100% |
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Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 21% |
Student > Master | 6 | 18% |
Student > Bachelor | 4 | 12% |
Student > Postgraduate | 4 | 12% |
Researcher | 2 | 6% |
Other | 4 | 12% |
Unknown | 6 | 18% |
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Medicine and Dentistry | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
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Mathematics | 1 | 3% |
Other | 2 | 6% |
Unknown | 5 | 15% |