Title |
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3
|
---|---|
Published in |
Nature Communications, March 2016
|
DOI | 10.1038/ncomms10959 |
Pubmed ID | |
Authors |
Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki |
Abstract |
Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic. |
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Country | Count | As % |
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Japan | 1 | 33% |
Unknown | 1 | 33% |
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Mendeley readers
Geographical breakdown
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Researcher | 18 | 16% |
Student > Master | 13 | 11% |
Student > Bachelor | 8 | 7% |
Other | 7 | 6% |
Other | 21 | 18% |
Unknown | 23 | 20% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 21 | 18% |
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