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The importance of immune evasion in the pathogenesis of rabies virus

Overview of attention for article published in Journal of Veterinary Medical Science, April 2016
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  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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3 X users

Citations

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111 Mendeley
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Title
The importance of immune evasion in the pathogenesis of rabies virus
Published in
Journal of Veterinary Medical Science, April 2016
DOI 10.1292/jvms.16-0092
Pubmed ID
Authors

ITO Naoto, Gregory W. MOSELEY, Makoto SUGIYAMA

Abstract

Rabies is a zoonotic disease caused by the Lyssavirus rabies virus (RABV) that can infect most mammals, including humans, where it has a case-fatality rate of almost 100%. Although preventable by vaccination, rabies causes c. 59,000 human fatalities every year worldwide. Thus, there exists an urgent need to establish an effective therapy and/or improve dissemination of vaccines for humans and animals. These outcomes require greater understanding of the mechanisms of RABV pathogenesis to identify new molecular targets for the development of therapeutics and/or live vaccines with high levels of safety. Importantly, a number of studies in recent years have indicated that RABV specifically suppresses host immunity through diverse mechanisms and that this is a key process in pathogenicity. Here, we review current understanding of immune modulation by RABV, with an emphasis on its significance to pathogenicity and the potential exploitation of this knowledge to develop new vaccines and antivirals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 <1%
Unknown 110 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 16%
Student > Master 14 13%
Researcher 8 7%
Student > Ph. D. Student 7 6%
Other 6 5%
Other 10 9%
Unknown 48 43%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 14%
Agricultural and Biological Sciences 10 9%
Immunology and Microbiology 9 8%
Veterinary Science and Veterinary Medicine 8 7%
Medicine and Dentistry 7 6%
Other 14 13%
Unknown 48 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2024.
All research outputs
#17,545,919
of 26,512,081 outputs
Outputs from Journal of Veterinary Medical Science
#1,250
of 3,601 outputs
Outputs of similar age
#187,018
of 317,016 outputs
Outputs of similar age from Journal of Veterinary Medical Science
#17
of 69 outputs
Altmetric has tracked 26,512,081 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,601 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,016 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.