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X Demographics
Mendeley readers
Attention Score in Context
| Title |
OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition
|
|---|---|
| Published in |
Cell Reports, April 2016
|
| DOI | 10.1016/j.celrep.2016.04.020 |
| Pubmed ID | |
| Authors |
Koji Kitazawa, Takafusa Hikichi, Takahiro Nakamura, Kanae Mitsunaga, Azusa Tanaka, Masahiro Nakamura, Tatsuya Yamakawa, Shiori Furukawa, Mieko Takasaka, Naoki Goshima, Akira Watanabe, Keisuke Okita, Satoshi Kawasaki, Morio Ueno, Shigeru Kinoshita, Shinji Masui |
| Abstract |
In development, embryonic ectoderm differentiates into neuroectoderm and surface ectoderm using poorly understood mechanisms. Here, we show that the transcription factor OVOL2 maintains the transcriptional program of human corneal epithelium cells (CECs), a derivative of the surface ectoderm, and that OVOL2 may regulate the differential transcriptional programs of the two lineages. A functional screen identified OVOL2 as a repressor of mesenchymal genes to maintain CECs. Transduction of OVOL2 with several other transcription factors induced the transcriptional program of CECs in fibroblasts. Moreover, neuroectoderm derivatives were found to express mesenchymal genes, and OVOL2 alone could induce the transcriptional program of CECs in neural progenitors by repressing these genes while activating epithelial genes. Our data suggest that the difference between the transcriptional programs of some neuroectoderm- and surface ectoderm-derivative cells may be regulated in part by a reciprocally repressive mechanism between epithelial and mesenchymal genes, as seen in epithelial-to-mesenchymal transition. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 3% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 28% |
| Student > Ph. D. Student | 16 | 20% |
| Student > Postgraduate | 7 | 9% |
| Student > Bachelor | 5 | 6% |
| Student > Master | 5 | 6% |
| Other | 11 | 14% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 38% |
| Medicine and Dentistry | 18 | 23% |
| Agricultural and Biological Sciences | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Social Sciences | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2023.
All research outputs
#3,331,278
of 25,373,627 outputs
Outputs from Cell Reports
#6,613
of 12,955 outputs
Outputs of similar age
#51,007
of 312,663 outputs
Outputs of similar age from Cell Reports
#119
of 263 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 263 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.