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Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus

Overview of attention for article published in Laboratory Medicine, April 2016
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Title
Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus
Published in
Laboratory Medicine, April 2016
DOI 10.1093/labmed/lmw015
Pubmed ID
Authors

Ranka N. Kangrga, Svetlana D. Ignjatović, Mirjana M. Dragašević, Snežana Ž. Jovičić, Nada T. Majkić-Singh

Abstract

The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion and metabolic control in patients with diabetes mellitus. We determined the presence of PE in specimens via enzyme-linked immunosorbent assay (ELISA), whereas serum fasting glucose, C-peptide, amylase, lipase, triglycerides, total 25(OH)-vitamin D, C-reactive protein (CRP), and hemoglobin A1c(HbA1c) concentrations were assayed using routine laboratory tests. PE values in 48 patients with diabetes were significantly lower than in 24 healthy volunteers (P = 001). In one-third of participants with diabetes mellitus, PE were less than 200 µg per g, indicating pancreatic functional insufficiency. Among the patients in the cohort, PE correlated positively with C-peptide levels (P = 04), lipase (P = 009), CRP (P = 04), sex (P = 03), and BMI (P = 02) but not significantly with duration of diabetes (P = 81) or levels of HbA1c(P = 87), amylase (P = 06), total 25(OH)-vitamin D (P = 16), or triglycerides (P = 52). Our results demonstrated a strong association of diabetes with low PE levels.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 26%
Researcher 5 13%
Lecturer 3 8%
Student > Postgraduate 3 8%
Student > Ph. D. Student 3 8%
Other 6 16%
Unknown 8 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 26%
Medicine and Dentistry 8 21%
Nursing and Health Professions 4 11%
Agricultural and Biological Sciences 2 5%
Immunology and Microbiology 2 5%
Other 4 11%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2019.
All research outputs
#15,260,579
of 25,914,360 outputs
Outputs from Laboratory Medicine
#540
of 1,285 outputs
Outputs of similar age
#157,177
of 317,562 outputs
Outputs of similar age from Laboratory Medicine
#10
of 14 outputs
Altmetric has tracked 25,914,360 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,285 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,562 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.