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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Arachidonic Acid Enhances Caffeine-Induced Cell Death via Caspase-Independent Cell Death
|
|---|---|
| Published in |
Scientific Reports, August 2012
|
| DOI | 10.1038/srep00577 |
| Pubmed ID | |
| Authors |
Hidekazu Kuwayama |
| Abstract |
Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does not possess caspase-dependent apoptotic machinery. Here, we observed that ablation of D. discoideumplaA, which encodes a phospholipase A2 (PLA₂) homolog, leads to a decreased rate of cell death under high caffeine concentrations and to enhanced cell death with the addition of arachidonic acid. Moreover, the inhibition of PLA₂ activity lead to a recovery of the survival rate in caspase-inhibited Hela cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death is enhanced via PLA₂-dependent signalling. Our results indicate that arachidonic acid may be a general second messenger that negatively regulates caffeine tolerance via a caspase-independent cell death cascade, which leads to multiple effects in eukaryotic cells. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 29% |
| United Kingdom | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 6% |
| Mexico | 1 | 6% |
| Unknown | 14 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 44% |
| Student > Ph. D. Student | 3 | 19% |
| Student > Bachelor | 2 | 13% |
| Professor > Associate Professor | 2 | 13% |
| Student > Master | 1 | 6% |
| Other | 1 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 38% |
| Biochemistry, Genetics and Molecular Biology | 3 | 19% |
| Physics and Astronomy | 3 | 19% |
| Immunology and Microbiology | 2 | 13% |
| Computer Science | 1 | 6% |
| Other | 1 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2012.
All research outputs
#4,146,388
of 22,673,450 outputs
Outputs from Scientific Reports
#32,646
of 122,149 outputs
Outputs of similar age
#29,294
of 167,579 outputs
Outputs of similar age from Scientific Reports
#76
of 207 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 122,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 207 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.