Title |
O impacto dos aditivos do tabaco na toxicidade da fumaça do cigarro: uma avaliação crítica dos estudos patrocinados pela indústria do fumo
|
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Published in |
Cadernos de Saúde Pública, January 2017
|
DOI | 10.1590/0102-311x00132415 |
Pubmed ID | |
Authors |
Francisco José Roma Paumgartten, Maria Regina Gomes-Carneiro, Ana Cecilia Amado Xavier de Oliveira |
Abstract |
Cigarette production involves a number of substances and materials other than just tobacco, paper and a filter. Tobacco additives include flavorings, enhancers, humectants, sugars, and ammonium compounds. Although companies maintain that tobacco additives do not enhance smoke toxicity and do not make cigarettes more attractive or addictive, these claims are questioned by independent researchers. This study reviewed the studies on the effects of tobacco additives on smoke chemistry and toxicity. Tobacco additives lead to higher levels of formaldehyde and minor changes in other smoke analytes. Toxicological studies (bacterial mutagenicity and mammalian cytoxicity tests, rat 90 days inhalation studies and bone-marrow cell micronucleus assays) found that tobacco additives did not enhance smoke toxicity. Rodent assays, however, poorly predicted carcinogenicity of tobacco smoke, and were clearly underpowered to disclose small albeit toxicologically relevant differences between test (with tobacco additives) and control (without tobacco additives) cigarettes. This literature review led to the conclusion that the impact of tobacco additives on tobacco smoke harmfulness remains unclear. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 18 | 23% |
Student > Master | 7 | 9% |
Student > Ph. D. Student | 6 | 8% |
Researcher | 3 | 4% |
Student > Doctoral Student | 1 | 1% |
Other | 2 | 3% |
Unknown | 41 | 53% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Medicine and Dentistry | 6 | 8% |
Chemistry | 6 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Psychology | 3 | 4% |
Other | 13 | 17% |
Unknown | 39 | 50% |