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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Induced pluripotent stem cells reprogramming: Epigenetics and applications in the regenerative medicine
|
|---|---|
| Published in |
Revista da Associação Médica Brasileira, February 2017
|
| DOI | 10.1590/1806-9282.63.02.180 |
| Pubmed ID | |
| Authors |
Kátia Maria Sampaio Gomes, Ismael Cabral Costa, Jeniffer Farias dos Santos, Paulo Magno Martins Dourado, Maria Fernanda Forni, Julio Cesar Batista Ferreira |
| Abstract |
Induced pluripotent stem cells (iPSCs) are somatic cells reprogrammed into an embryonic-like pluripotent state by the expression of specific transcription factors. iPSC technology is expected to revolutionize regenerative medicine in the near future. Despite the fact that these cells have the capacity to self-renew, they present low efficiency of reprogramming. Recent studies have demonstrated that the previous somatic epigenetic signature is a limiting factor in iPSC performance. Indeed, the process of effective reprogramming involves a complete remodeling of the existing somatic epigenetic memory, followed by the establishment of a "new epigenetic signature" that complies with the new type of cell to be differentiated. Therefore, further investigations of epigenetic modifications associated with iPSC reprogramming are required in an attempt to improve their self-renew capacity and potency, as well as their application in regenerative medicine, with a new strategy to reduce the damage in degenerative diseases. Our review aimed to summarize the most recent findings on epigenetics and iPSC, focusing on DNA methylation, histone modifications and microRNAs, highlighting their potential in translating cell therapy into clinics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 135 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 35 | 26% |
| Student > Master | 21 | 16% |
| Student > Ph. D. Student | 20 | 15% |
| Student > Postgraduate | 9 | 7% |
| Researcher | 7 | 5% |
| Other | 13 | 10% |
| Unknown | 30 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 33% |
| Medicine and Dentistry | 15 | 11% |
| Agricultural and Biological Sciences | 12 | 9% |
| Neuroscience | 6 | 4% |
| Immunology and Microbiology | 4 | 3% |
| Other | 21 | 16% |
| Unknown | 33 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from Revista da Associação Médica Brasileira
#646
of 1,105 outputs
Outputs of similar age
#322,774
of 424,972 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#12
of 18 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,972 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.