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Toxicology of Lapachol in rats: embryolethality

Overview of attention for article published in Revista Brasileira de Biologia, February 2001
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  • Good Attention Score compared to outputs of the same age (78th percentile)

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Title
Toxicology of Lapachol in rats: embryolethality
Published in
Revista Brasileira de Biologia, February 2001
DOI 10.1590/s0034-71082001000100021
Pubmed ID
Authors

M. de O. GUERRA, A. S. B. MAZONI, M. A. F. BRANDÃO, V. M. PETERS

Abstract

Lapachol is a naphtoquinone with therapeutic potential against enterovirus, Chagas disease and is also used as an antimalarial and antiinflamatory agent. In order to study teratogenic potential of Lapachol, pregnant Wistar rats were treated with 0.5 ml of distilled water (control group); 0.5 ml of hydroalcoholic solution (vehicle group) and 10 mg of Lapachol in 0.5 ml of hydroalcoholic solution (treated group) by oral gavage from the 8th to the 12th day of pregnancy. The following variables were observed: maternal body weight on days 1, 6, l5 and 21 and food intake on days 2, 6, 15 and 21 of pregnancy. The number of live and dead fetuses and the sites of resorptions were counted. The ovaries were weighed and the corpora lutea were counted. Data were analyzed by ANOVA-one way, Dunnett test and the chi square test. Significance level test alpha = 0.05. Results have shown that mothers were unaffected but there were a 99.2% of fetus mortality, indicative of a strong abortifacient effect of Lapachol in rats.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 18%
Researcher 6 18%
Student > Postgraduate 6 18%
Student > Master 6 18%
Student > Doctoral Student 3 9%
Other 5 15%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 29%
Pharmacology, Toxicology and Pharmaceutical Science 5 15%
Chemistry 4 12%
Biochemistry, Genetics and Molecular Biology 3 9%
Social Sciences 2 6%
Other 7 21%
Unknown 3 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2022.
All research outputs
#7,575,349
of 25,986,827 outputs
Outputs from Revista Brasileira de Biologia
#1
of 1 outputs
Outputs of similar age
#21,333
of 115,227 outputs
Outputs of similar age from Revista Brasileira de Biologia
#1
of 2 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 4.0. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 115,227 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them