Title |
Müllerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer
|
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Published in |
Clinics, August 2000
|
DOI | 10.1590/s0041-87812000000100004 |
Pubmed ID | |
Authors |
Filomena Marino Carvalho, Jesus Paula Carvalho, Eduardo Vieira da Motta, Jorge Souen |
Abstract |
Müllerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Lecturer | 2 | 18% |
Researcher | 2 | 18% |
Student > Bachelor | 2 | 18% |
Other | 1 | 9% |
Student > Master | 1 | 9% |
Other | 1 | 9% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
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Neuroscience | 1 | 9% |
Unknown | 1 | 9% |