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Mendeley readers
| Title |
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats
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|---|---|
| Published in |
Acta Cirurgica Brasileira, March 2017
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| DOI | 10.1590/s0102-865020170030000004 |
| Pubmed ID | |
| Authors |
Sylvio Valença de Lemos Neto, Isabela Galvão Vianna, Yara Marcondes Machado Castiglia, Marjorie de Assis Golim, Aparecida Vitória Gonçalves de Souza, Lídia Raquel de Carvalho, Elenice Deffune, Paulo do Nascimento Junior, Norma Sueli Pinheiro Módolo, Pedro Thadeu Galvão Vianna |
| Abstract |
To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5 mg.kg-1, five minutes before reperfusion. Comparison groups were isoflurane and propofol sham groups and isoflurane and propofol ischemia-reperfusion-induced renal injury. Renal tubular cell viability was quantitatively assessed by flow cytometry after cell culture and classified as early apoptosis, necrotic cells, and intact cells. Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups. Necrosis percentage was significantly higher in propofol-anesthetized animals subjected to renal ischemia-reperfusion injury. The percentage of intact cells was lower in both, isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury. In a model of ischemia-reperfusion-induced renal injury, cyclosporine A, 5 m.kg-1, administered five minutes before renal reperfusion in rats with acute-induced hyperglycemia under either isoflurano or propofol anesthesia, attenuated early apoptosis and preserved viability in renal tubular cells, regardless of the anesthetic used. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 3 | 23% |
| Researcher | 2 | 15% |
| Student > Ph. D. Student | 2 | 15% |
| Lecturer | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 4 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 38% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
| Mathematics | 1 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 8% |
| Immunology and Microbiology | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 2 | 15% |