Title |
The Indispensable Roles of Microglia and Astrocytes during Brain Development
|
---|---|
Published in |
Frontiers in Human Neuroscience, November 2016
|
DOI | 10.3389/fnhum.2016.00566 |
Pubmed ID | |
Authors |
Kitty Reemst, Stephen C. Noctor, Paul J. Lucassen, Elly M. Hol |
Abstract |
Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease. |
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Country | Count | As % |
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Netherlands | 3 | 30% |
United Kingdom | 1 | 10% |
Chile | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 80% |
Practitioners (doctors, other healthcare professionals) | 2 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | <1% |
Germany | 1 | <1% |
Unknown | 890 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 185 | 21% |
Student > Bachelor | 137 | 15% |
Student > Master | 129 | 14% |
Researcher | 95 | 11% |
Student > Doctoral Student | 46 | 5% |
Other | 83 | 9% |
Unknown | 217 | 24% |
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---|---|---|
Neuroscience | 252 | 28% |
Agricultural and Biological Sciences | 136 | 15% |
Biochemistry, Genetics and Molecular Biology | 122 | 14% |
Medicine and Dentistry | 44 | 5% |
Immunology and Microbiology | 17 | 2% |
Other | 73 | 8% |
Unknown | 248 | 28% |