Title |
DNA Damage Response and Autophagy: A Meaningful Partnership
|
---|---|
Published in |
Frontiers in Genetics, November 2016
|
DOI | 10.3389/fgene.2016.00204 |
Pubmed ID | |
Authors |
Aristides G. Eliopoulos, Sophia Havaki, Vassilis G. Gorgoulis |
Abstract |
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein, we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the mechanisms by which autophagy and DDR are intertwined provides novel insight into the pathobiology of conditions associated with accumulation of DNA damage, including cancer and aging, and novel concepts for the development of improved therapeutic strategies against these pathologies. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Unknown | 179 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 21% |
Student > Master | 30 | 17% |
Student > Bachelor | 24 | 13% |
Researcher | 17 | 9% |
Student > Doctoral Student | 15 | 8% |
Other | 22 | 12% |
Unknown | 34 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 70 | 39% |
Agricultural and Biological Sciences | 23 | 13% |
Medicine and Dentistry | 15 | 8% |
Immunology and Microbiology | 8 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Other | 14 | 8% |
Unknown | 43 | 24% |