Title |
Molecular Determinants of Regulatory T Cell Development: The Essential Roles of Epigenetic Changes
|
---|---|
Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2013.00106 |
Pubmed ID | |
Authors |
Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi |
Abstract |
Regulatory T (Treg) cells constitute a distinct T cell subset, which plays a key role in immune tolerance and homeostasis. The transcription factor Foxp3 controls a substantial part of Treg cell development and function. Yet its expression alone is insufficient for conferring developmental and functional characteristics of Treg cells. There is accumulating evidence that concurrent induction of Treg-specific epigenetic changes and Foxp3 expression is crucial for lineage specification and functional stability of Treg cells. This review discusses recent progress in our understanding of molecular features of Treg cells, in particular, the molecular basis of how a population of developing T cells is driven to the Treg cell lineage and how its function is stably maintained. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 1% |
United States | 2 | 1% |
Sweden | 1 | <1% |
Italy | 1 | <1% |
Japan | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 149 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 39 | 25% |
Researcher | 27 | 17% |
Student > Master | 16 | 10% |
Student > Doctoral Student | 15 | 10% |
Student > Bachelor | 10 | 6% |
Other | 35 | 22% |
Unknown | 15 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 47 | 30% |
Immunology and Microbiology | 40 | 25% |
Medicine and Dentistry | 29 | 18% |
Biochemistry, Genetics and Molecular Biology | 16 | 10% |
Psychology | 2 | 1% |
Other | 5 | 3% |
Unknown | 18 | 11% |