Chapter title |
Mammalian Actins: Isoform-Specific Functions and Diseases
|
---|---|
Chapter number | 43 |
Book title |
The Actin Cytoskeleton
|
Published in |
Handbook of experimental pharmacology, January 2016
|
DOI | 10.1007/164_2016_43 |
Pubmed ID | |
Book ISBNs |
978-3-31-946369-8, 978-3-31-946371-1
|
Authors |
Christophe Ampe, Marleen Van Troys |
Editors |
Brigitte M. Jockusch |
Abstract |
Actin is the central building block of the actin cytoskeleton, a highly regulated filamentous network enabling dynamic processes of cells and simultaneously providing structure. Mammals have six actin isoforms that are very conserved and thus share common functions. Tissue-specific expression in part underlies their differential roles, but actin isoforms also coexist in various cell types and tissues, suggesting specific functions and preferential interaction partners. Gene deletion models, antibody-based staining patterns, gene silencing effects, and the occurrence of isoform-specific mutations in certain diseases have provided clues for specificity on the subcellular level and its consequences on the organism level. Yet, the differential actin isoform functions are still far from understood in detail. Biochemical studies on the different isoforms in pure form are just emerging, and investigations in cells have to deal with a complex and regulated system, including compensatory actin isoform expression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 25% |
Student > Bachelor | 8 | 14% |
Researcher | 8 | 14% |
Student > Doctoral Student | 6 | 11% |
Student > Master | 6 | 11% |
Other | 4 | 7% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 24 | 42% |
Agricultural and Biological Sciences | 7 | 12% |
Medicine and Dentistry | 7 | 12% |
Environmental Science | 1 | 2% |
Chemical Engineering | 1 | 2% |
Other | 4 | 7% |
Unknown | 13 | 23% |